Direct Link Immune System And The Brain — Profound Implications For Neurology

 Direct Link Immune System And The Brain – Vessels Found By Antoine Louveau, PhD,
Posted: 01 Jun 2015 09:24 AM PDT
In a stunning discovery that overturns decades of textbook teaching, researchers have determined that the brain is directly connected to the immune system by vessels previously thought not to exist. The discovery could have profound implications for diseases from autism to Alzheimer’s to multiple sclerosis.

“Instead of asking, ‘How do we study the immune response of the brain?’ ‘Why do multiple sclerosis patients have the immune attacks?’ now we can approach this mechanistically. Because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,” said Jonathan Kipnis, PhD, professor in the UVA Department of Neuroscience and director of UVA’s Center for Brain Immunology and Glia (BIG). “It changes entirely the way we perceive the neuro-immune interaction. We always perceived it before as something esoteric that can’t be studied. But now we can ask mechanistic questions.”

“We believe that for every neurological disease that has an immune component to it, these vessels may play a major role,” Kipnis said. “Hard to imagine that these vessels would not be involved in a [neurological] disease with an immune component.” …

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Missing link found between brain, immune system; major disease implications

University of Virginia Health System. “Missing link found between brain, immune system; major disease implications.” ScienceDaily. ScienceDaily, 1 June 2015. <www.sciencedaily.com/releases/2015/06/150601122445.htm>.
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Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris, Jonathan Kipnis. Structural and functional features of central nervous system lymphatic vessels. Nature, 2015; DOI: 10.1038/nature14432

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8. Conversations With Bump Onna Log

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BUMP ONNA LOG:      It’s OK. There is nothing to feel bad about. I don’t care that you have this neuro-whatever thing, as long as it doesn’t get in the way of me doing what I like to do, or me going on the trips that I enjoy.

BEAR:   So it doesn’t bother you that I have an incurable degenerative disorder that has been causing me pain, agony, anguish, suffering and grief for many years, will continue to do so, and  this diagnosis  confirms it will only get worse?

BUMP ONNA LOG:      Why should it bother me?

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Bear … 05.12.2015
ⓒBearspawprint2015

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For an explanation (ha!) and links: Bump Onna Log

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Difficult Dawn

.
.
Just before
Dawning sun
Arrives
Exhaustion
Too weary
To rest
Too late
For sleep
Something
Akin to
Hunger calls
My skin
To carry
The weight
Of my flesh
Quivering
Into day
Reluctance
Makes more
Effort
Required
Trembling
I watch
Dripping trees
Gain color
While busy
Birds call
Greetings
Singing
With their
Tasks I am
Burdened
With fear
Least I
Falter
My body
Unreliable
Does shame
Or love
Compel
Strength
Does my own
Pain matter
When there
Is work
To be done
Every moment
I must
Evaluate
How to
Do what
Needs doing
Without
Endangering
Others
What can be
Omitted
Easier to
Be alone

Selfishly
I pray
For myself
Please help
Me be cheerful
Today belongs
To my small
Granddaughter

The trees
The birds
Voice an answer
I am grateful
.
.
Bear … 04.14.2015
ⓒBearspawprint2015

I Am Not

.
.
What is that
That is eating me
My own nerves
Chewing through
My skin biting
Going out and
Gouging going in
Dis-aesthesia’s
Tattooed arabesque
.
What is
This darkness
That slides
Down the wall
Wilting flowers
Growing mildew
In my books
All words replaced
With landscapes
Confused with corruption
.
Veiled curtains
Rotting as I watch
Do I truly want
To see beyond
Silvered mirrors
Flake away
Revealing reflected
Shadowed faces
Almost unseen
Uncaring of wild
Tangled hair
.
Unnoticed settling
Heavy in my heart
The weary darkness
Bathes me
In rivers of nettles
My body dances
A jigging cramping reel
Spastic leaps
Escaping from myself
Macabre’ stars
I am not
.
Each half thought
Letter by letter
Dragged heavy
With sticky mud
Unwashed dropped
Just outside
In night again
I am not
.
What is gone
Something
There was
Something
That was here
Just before
I flew through
The missing roof
I was here
Balanced comfortable
On the cross beams
.
I am not
.
My self traded
For muddy letters
Discarded
.
I am gone
My body is hollow
A shell of pain
There is no one here
I am not
.
Shall spring arrive
Draped in black
Bees swarming
Eternal night
Hives empty
Black carpenter
Ants constructing
Termite wars
.
Merely
It is that
I am not
In my place
A fire burns
.
.
Bear … 01.04.2015
ⓒBearspawprint2015
.
.

Choke The Stars

.
.
Thick black
Fear Washes
Red over
the stars
Coalescing
Turning
Purple
A million
Dazzling
Pinwheels
Behind
My eyes
Below
Ground
Below oceans
Darkness
Erupting
Swirling
To blackness
Beneath
Movement
All around
Resonates
Roars
Too aware
Too much
Hot
A million
Electric
Fires burn
Each synapse
Arching
I leap
And jig
And dance
And cry
Silent
Until oily
Screams
Ululate
Terror
Chokes
The stars
Chokes
The sky
Starves
Song
There is
Nowhere
Without
Dread
And the
Black fires
Overtake
And I
Succumb
And everywhere
Is
Myself
I am
All memory
Not insane
And there is
No death
And there
Is no
Escape
And there is
No hope
And there is
No eternity
And there is
Nothing
.
.
.
Bear … 10.24.2014
ⓒBearspawprint2014

Summoning Granny Magic

.
.
From where
May I
Summon energy?
My body
Has none.
.
Nerve fatigue
Overwhelms.
I am running
In deficit.
.
Sometimes
Effort,
Beyond my
Capabilities,
Is required.
.
I must borrow
From tomorrow.
.
The Chi is
Becoming equalized
Within my body,
And surrounding.
.
I must evoke
A great deal
Of Granny Magic.
.
I am grateful.
The Magic
Is possible.
.
This long day
Will become
A happy memory.
.
The morrow
Of returns
Will come
Soon enough.
.
Today,
A small child
Is expecting
Her Granny,
With open arms.
.
Granny Magic
Turns everything
Into love filled fun.
Children know.
.
.
Bear … 09.02.2014
ⓒBearspawprint 2014

Gettting Old Again

.
.
There is nothing there
Except more and more work
Their false remorse I must
Sooth away with platitudes of
False memory and forgiveness joy

I know sighted guide
I have the needed skills
To help the geriatric blind
I understand all too well
Helpless procrastination

I am able to debate and interpret
Their deep core faith though
I believe not piles of mealy mouth
Words while I hopelessly cook
Their food that I can not eat

Just for their pleasure
I can be the jolly punster
And soothingly joke as we
Struggle to get clean and clothed
And I do the laundry out of sight

But for me there is nothing
There except memory to avoid
And more work to do
And the hot house heat
Steaming the holes in my brain

Whether here or there
I am alone and my pain lives
Within me to travel along
Company to sooth my aloneness
My love is merely compassion
.
.
Bear …07.31.2014
ⓒ Bearspawprint 2014
.
.
Soon enough, my turn. With my bad attitude nobody will be able to tolerate me!!!

Enthralled

.
.

To escape this mess

Which replenishes

Itself expanding

In exponential

Doubling lives

That kill

I shall interrupt

And digress

And drink coffee

And swing my feet

While sitting on

The bulldozed porch

Of your memory house

Or in the ashes

Of my ancient

Burned Tangerine Tree

Or relaxing reposed

In the Aspen Grove

That hides

Quaking shimmering

Under side-walks

And grocery stores

I shall speak to you

Or no one and jabber

Adult nonsense

Hello I am fine as

I pretend not to weep

You will recognize me

By the smile in my eyes

As I sit trapped

On the floor entralled

By children

Drowning in laughter

I cannot rise

Above such moments

Which are

Eternity preserved

.
Bear … July 2014
ⓒ Bearspawprint 2014
.
.
.

Drudge of Joy

.
.
What can I do?
There is nothing.
I can only begin
The start of almost,
Then all energy is depleted.
I initiate the end
Without ever beginning.
Spirit must fill the void.
Spirit must force my body
To clear away the dangers.
My shame is in weariness.
My strength fails me.
Where is the will?
Sometimes effort
Makes no difference.
Too much is damaged.
Too much is lost.
Too much.
So now I begin again,
Feast preparations.
For the children
And the children’s children,
I am a drudge of joy.
The joy is real,
The work a torment.
Perhaps again the
Punishment can be delayed.
Please let it be so.
How can I allow collapse
With so much expectation?
The dread is real,
The flares of electric agony
Are real also.
Pain is exhausting without
Relief for rest.
Distraction is the relief.
Words written to myself
My resting peace.
May this peace be enough.
Please let it be so.
I am a drudge of joy.
.
.
Bear … 04.04.2014
ⓒ Bearspawprint
.
.